• We conducted the largest drug screen to date

  2025-01-17

  

  We conducted the largest drug screen to date in HPV-positive cancers and identified Aurora kinase inhibitors as effective and understudied drugs in HNSCC and CESC. These drugs cause apoptosis and cell cycle arrest in vitro and decrease tumor size in vivo. This is the first published study to demonst

• Nitric oxide carrier To maintain ATP levels postmortem muscl

  2025-01-17

  

  To maintain ATP levels, postmortem muscle mobilizes its glycogen reserves to yield Nitric oxide carrier 6-phsphate that proceeds through glycolysis. Glycogen degradation was affected by the interaction between treatment and time (P extended pH decline, as it allows for more substrate to pass PFK-1 b

• br Conflicts of interest br Contributors br Introduction Lip

  2025-01-16

  

  Conflicts of interest Contributors Introduction Lipid oxidation and enzymatic activities are some of the most significant problems in the food industry. These reactions lead to changes in chemical composition which in turn reduce the quality and shelf life of food products. Most of the anti

• Thiol are reduced by two major redox systems glutathione glu

  2025-01-16

  

  Thiol are reduced by two major redox systems, glutathione/glutaredoxin (GRX) and thioredoxin (TRX), which have been extensively studied in plants [13], [14], [15]. Glutathione, a thiol-containing tripeptide, exists in a reduced (GSH) or an oxidized form (GSSG). It has a major role as a redox buffer.

• In conclusion there are only a few experimental reports eval

  2025-01-16

  

  In conclusion, there are only a few experimental reports evaluating the influence of LP533401 hcl on allergy. With the exception of studies using macrolides, most point to their harmful effect on the severity of this disease. Future studies will be crucial to define the impact of antibiotic use on

• While we chose to divide our etiologies

  2025-01-16

  

  While we chose to divide our etiologies into three categories, it should be noted that such division has certain limitations. Even though URIs and the common cold are considered mainly viral in origin and rhinosinusitis mainly bacterial in origin,26, 27 there is considerable overlap between these co

• However a high triglyceride level was associated with dement

  2025-01-16

  

  However, a high triglyceride level was associated with dementia in a study with subjects aged ≥65 years (Raffaitin et al., 2009). In another study, the serum triglyceride levels of three different transgenic mouse strains mimicking AD were also evaluated within the progression of the pathology. In o

• In this study using pure enzyme

  2025-01-16

  

  In this study, using pure enzyme preparations of human placental recombinant AR (hAR) and of AR isolated from bovine lens (bAR), which behave as Michaelis 9620 with glyceraldehyde as substrate, is shown that an apparent negative cooperativity action for glucose still occurs. We present evidence for

• Rising depolarization was observed during and decaying depol

  2025-01-16

  

  Rising depolarization was observed during and decaying depolarization after the photostimulation (Fig. 1D). The slow decrease of the firing rate after photostimulation is also a remarkable characteristic of the striatal neuron (Figs. 1E, 2 and 3), since the cortex pyramidal neurons (data not shown)

• Notably both circulating adiponectin and

  2025-01-16

  

  Notably, both circulating adiponectin and adipsin were equally diminished by about 50% in Arfrp1 mice consistent with several studies reporting overlapping trafficking routes for their secretion from 3T3-L1 Molecular chaperone modulator which was strikingly inhibited upon ablation of TfR-positive e

• br Expression of ADK in the normal brain

  2025-01-16

  

  Expression of ADK in the normal brain In adult brain, ADK is primarily expressed in astrocytes. Immunocytochemical analysis of adult rat and mouse Endogenous opioid peptide revealed predominant astrocytic expression throughout the hippocampus and cortex. Two isoforms of ADK have been identified i

• At the last follow up nine patients had discontinued pyridos

  2025-01-16

  

  At the last follow-up, nine patients had discontinued pyridostigmine within the first year postoperatively. Only one patient required pyridostigmine at a higher dose, but this was accompanied by successful weaning of prednisolone. None of the 5 patients who were on pyridostigmine treatment alone pri

• br Conclusion Biotransformation of trachyloban oic acid by

  2025-01-16

  

  Conclusion Biotransformation of trachyloban-19-oic Imidazoline receptor antagonist by S. racemosum provided three products. Oxidation of compound 1 at C-17 (2–3), as well as rearrangement of 1 into a kaurane diterpene hydroxylated in C-16 and C-17 (4) were crucial for increasing AChE inhibitory

• br Acknowledgments This work was supported by

  2025-01-16

  

  Acknowledgments This work was supported by the R&D Program of the Institutional Research Program of KRICT (SI1701-02), and by the Next generation carbon upcycling project of Ministry of Science and ICT. JSC is kindly grateful to the National Research Council of Science and Technology (NST) for fi

• Cost-effective MTT assay kit for laboratory use Many reports

  2025-01-15

  

  Many reports have well documented that signaling pathways play a pivotal role in controlling longevity. The most studied of these pathways is the IGF-1 pathway [11,12]. A disruption of this pathway has been found to extend longevity in different groups of species starting from Caenorhabditis elegans

15964 records 30/1065 page Previous Next First page 上5页 2627282930 下5页 Last page