• Previous research has suggested that differences in spatiote

  2021-09-26

  

  Previous research has suggested that differences in spatiotemporal regulation of intracellular signaling pathways can confer specificity to cellular responses (Marshall, 1995). Conventional approaches based on gain- or loss-of-function genetic manipulations or small-molecule inhibitors, however, lac

• flt3 br Introduction Isoprenoid structures play

  2021-09-26

  

  Introduction Isoprenoid structures play an essential role in biology and over 30,000 natural products of this class are known (Greenhagen et al., 2003). Like other animals, insects require these compounds for many disparate processes, including electron transport (e.g., ubiquinones), protein glyc

• To evaluate the role of increased FPPS expression in

  2021-09-26

  

  To evaluate the role of increased FPPS expression in paclitaxel-treated cells, we investigated the effects of FPPS on R788 progression. DNA content analysis showed that the number of cells accumulating in the G/M phase increased in a dose-dependent manner in paclitaxel-treated cells (A and B), howev

• flavopiridol We have expanded these studies by doing EEG rec

  2021-09-26

  

  We have expanded these studies by doing EEG recording in the ET-1 model. Using this technique, we demonstrated that activation of either the ETA flavopiridol or the ETB receptor induces electrical seizures. ET-1 induced electrical seizures occurred in the presence of either the ETA receptor antagon

• But some experiments did not support the

  2021-09-26

  

  But some experiments did not support the antinociceptive role of GalR2 in peripheral locations beyond the DRG. The partial saphenous nerve ligation and the complete Freund's adjuvant model in the rats demonstrated that close intra-arterial infusion of galanin, but not galanin (2–11), reduced cooling

• At this point it needs however to be mentioned

  2021-09-26

  

  At this point it needs, however, to be mentioned that most in vivo studies regarding the herein discussed nuclear receptors were performed in rodents, especially in mice. Due to the significant differences in metabolism in mice and humans, not all results are translatable between these species and h

• Fluorouracil Statins are recognized by their nephroprotectiv

  2021-09-26

  

  Statins are recognized by their nephroprotective effect (Chmielewski et al., 2002). The hepato- and nephroprotective effects of silymarin are also well studied (Alqasoumi, 2014, Mohamed et al., 2018). Several studies documented increasing Fluorouracil of FXR by statins (Byun et al., 2014& (Lu et al.

• Toc and Toc are GTPases that regulate initial steps

  2021-09-24

  

  Toc34 and Toc159 are GTPases that regulate initial steps of preprotein import [3,4,26]. It was shown that GTP hydrolysis of at least one receptor is necessary to initiate the translocation process [23,27]. As reported for other small G-proteins, Toc34 and Toc159 bind their cargo in a nucleotide-depe

• br Conflict of interest br Acknowledgement br

  2021-09-24

  

  Conflict of interest Acknowledgement Exposure to tobacco smoke in early life has been found to increase the risk of developing asthma and lung function deficits in adolescence and adulthood., , , , However, not all children exposed to tobacco smoke in early life develop asthma, which sugges

• Finally we investigated increasing basicity as a way to

  2021-09-24

  

  Finally, we investigated increasing basicity as a way to improve solubility. We expected that conversion of the ether linkage of to an -methyl group could improve solubility. More than expected, Prednisolone demonstrated significant improvement of values of solubility for the two media, especially f

• The combination of niacin with a

  2021-09-24

  

  The combination of niacin with a selective PGD2 receptor antagonist laropiprant, designed to circumvent the flushing side effect of niacin, has been evaluated in the HPS2-THRIVE study and showed no clinically meaningful benefit when administered in patients on top of statin therapy [41]. Our data su

• Loteprednol etabonate synthesis In breeding season small mam

  2021-09-24

  

  In breeding season, small mammals increase dispersal and social communication to maximize their opportunity to mate. In the present study, we found that gerbils in April showed more locomotion and exploratory behavior in the open field test. Moreover, subadult gerbils in April and July were more lik

• We observed the reduced expression of the GluN

  2021-09-24

  

  We observed the reduced expression of the GluN2a subunit in the temporal and entorhinal cortexes and ventral hippocampus, which may result in the predominance of GluN2b-containing NMDA receptors during the latent period. Previously, using the same model, we revealed the reduction of the GluN2a/GluN2

• br Methods br Results br Discussion In this

  2021-09-24

  

  Methods Results Discussion In this series of studies we hypothesized that FHH-GHSRm1/Mcwi rats would, relative to their WT counterparts, exhibit a metabolic and behavioral phenotype reminiscent of GHSR−/− mice. Through the use of the GHSR−/− mouse, a great deal about the role of ghrelin sig

• Autophagy plays a multifaceted role in

  2021-09-24

  

  Autophagy plays a multifaceted role in regulating both the quality and quantity of protein (e.g., protein half-life and activity) and organelles (e.g., mitochondrial number and function), thus determining cell fate [15]. The induction of autophagy has been generally considered a programmed cell surv

15569 records 541/1038 page Previous Next First page 上5页 541542543544545 下5页 Last page