• On the basis of the

  2021-05-08

  

  On the basis of the published articles, it is known that chemokines are produced by leukocytes and tissue cells, constitutively or after induction. Chemokines are responsible for the recruitment of leukocytes to maintain proper functioning of the immune system [14]. They exist in the central nervous

• The conventional medical therapy for IBD consists

  2021-05-08

  

  The conventional medical therapy for IBD consists in reducing the inflammatory response using various strategies that exert severe side-effects, a strategy that also decreases the risk of colon carcinoma [13], [14]. During the last decade, the activation of the cholinergic system has been proposed f

• In contrast to PEGylated proteins which tend to have reduced

  2021-05-08

  

  In contrast to PEGylated proteins which tend to have reduced MnTBAP Chloride in the body relative to their native counterparts, proteins conjugated to albumin tend to accumulate in certain locales in vivo. This means that albumin-based drug carrier systems have particular applications in the field

• Though limited to a large cohort of self reported

  2021-05-07

  

  Though limited to a large cohort of self-reported healthy individuals, associations between individual Cryptotanshinone receptor have been identified which may be clinically significant. Though slight, there is a relationship between the CYP2D6-inferred metabolizer phenotype and the diplotype-predi

• Notochord is a transient structure differentiating at early

  2021-05-07

  

  Notochord is a transient structure differentiating at early stage during embryogenesis that is at the origin of vertebral bodies in all vertebrates. In zebrafish, it is composed of vacuolated Fomepizole surrounded by a unique ECM structure improperly called notochordal BM. As in chicken and amphibi

• br Conclusion In this review

  2021-05-07

  

  Conclusion In this review, we have discussed how inhibition of the CK2/CDK5 signaling axis protects WM only when inhibited before ischemia, while inhibition of the CK2/AKT/GSK3β signaling axis protects WM either before or after an ischemic injury in young, aging, and old WM (Fig. 3). CK2 activati

• A limitation of this study

  2021-05-07

  

  A limitation of this study is the between-study heterogeneity of the datasets analyzed. To address this heterogeneity, we used a random-effects model in our analysis. Also, only 2 of the databases provided information on sex, and as a result, the sex-specific analyses were performed with a smaller

• Identification of the drug to be used as

  2021-05-07

  

  Identification of the drug to be used as first-step antihypertensive treatment has always been, and remains, a matter of debate. The decision wihich drug (or drug combination) to choose as first-line therapy depend on many variables such as coexisting metabolic disorders, obesity, presence of subcl

• Enhanced oxidative stress has been suggested

  2021-05-07

  

  Enhanced oxidative stress has been suggested as the critical mechanisms of IS-produced muscle damage [41,42]. NAC as a direct reactive oxygen species ROS scavenger is frequently discussed in the clinical trials of radiocontrast-induced AKI prevention [43]. Despite some supportive epidemiological dat

• Nimodipine is an L type calcium

  2021-05-07

  

  Nimodipine is an L-type calcium channel antagonist that reduces excessive calcium influx during pathological conditions, contributing to its neuroprotective properties (Zornow and Prough, 1996; Kobayashi and Mori, 1998). Autophagy can be induced by increased [Ca2+] (Rami et al., 2008). Nimodipine si

• Similarly in the EAE model Chalmin et

  2021-05-07

  

  Similarly in the EAE model, Chalmin et al. previously demonstrated that EBI2 and CH25H might be responsible for the efficient egress of differentiated Th17 cells from the draining lymph nodes [31]. As discussed above, in active EAE we did not find differences in EAE development and only the transfer

• br Conclusion br Introduction br CRL E ligases

  2021-05-07

  

  Conclusion Introduction CRL4 E3 ligases in tumorigenesis Small molecule-based PROTACs PROTAC: Major biological impacts Acknowledgements The authors sincerely apologize to all those colleagues whose important work was not cited in this paper owing to space limitations. They thank t

• Betaine Concerning family A GPCRs although it has been

  2021-05-07

  

  Concerning family A GPCRs, although it has been described that several receptors are able to operate as monomers (Arcemisbéhère et al., 2010; Bayburt et al., 2011; Chabre & le Maire, 2005; Ernst, Gramse, Kolbe, Hofmann, & Heck, 2007; Hanson et al., 2007; Kuszak et al., 2009; Whorton et al., 2007), e

• Consistent with our previous study Gao et

  2021-05-07

  

  Consistent with our previous study (Gao et al., 2018b; Wu et al., 2018), we found that TCB-2 disrupted both pup preference and home-cage maternal behavior. Based on the findings that 4-h pup Ademetionine (a technique presumably increases maternal motivation) failed to attenuate the TCB-2-induced ma

• Our finding that activating DDR variants are

  2021-05-06

  

  Our finding that activating DDR2 variants are a cause of this disease suggested that the ABL inhibitor dasatinib, a leukemia drug that also inhibits DDR2, could be used for treatment of affected individuals.10, 11 To examine the effect of dasatinib on p.Leu610Pro- and p.Tyr740Cys-induced autophospho

15853 records 634/1057 page Previous Next First page 上5页 631632633634635 下5页 Last page