• LTD and LTC cause contraction

  2020-07-02

  

  LTD4 and LTC4 cause contraction in the rat stomach and these contractions are sensitive to CysLT1 receptor antagonists (Goldenberg and Subers, 1983, Miura et al., 1992, Miyata et al., 1995). However, effects of other leukotrienes in the gastric contraction and inhibitory effects of potent, selective

• PFI 3 synthesis br Methods br Results br Discussion

  2020-07-02

  

  Methods Results Discussion MEN91507 is a potent and selective CysLT1 receptor antagonist. Guinea-pig lung membranes have been widely used for the detection and characterization of CysLT1 receptor antagonists: in this assay the high affinity (subnanomolar) binding of [3H[leukotriene D4 or [3

• Introduction Cyclin dependent kinases CDKs are a family

  2020-07-02

  

  Introduction Cyclin dependent kinases (CDKs) are a family of proline-directed serine/threonine kinases with roles in regulation of crucial cellular processes such as iox and transcription [1]. One of the unifying features of this family is its dependence on association with cyclins/cyclin-like reg

• br Conclusion br Introduction Interleukin

  2020-07-02

  

  Conclusion Introduction Interleukin (IL)-18 [1] is a member of the IL-1 cytokine family activating corner stones of inflammatory signaling, among others nuclear factor (NF)-κB and p38 mitogen-activated protein kinase. Striking similarities exist between IL-1β and IL-18 including processing by

• br Transparency document br Acknowledgements

  2020-07-01

  

  Transparency document Acknowledgements This work was supported by research grant G092715N of the Research Foundation Flanders (FWO). The authors are indebted to Drs. V. Baekelandt and E. Lobbestael (Research Group for Neurobiology and Gene Therapy, KU Leuven) for stimulating discussions and he

• Fig shows graphically the abundance distributions of the ARD

  2020-07-01

  

  Fig. 3 shows, graphically, the abundance distributions of the ARD% of the investigated data with both the CPA-NRTL and CPA-UNIQUAC models, where ARD% is defined as,in which x and x are the experimental and calculated SO2 molar compositions in the liquid phase, respectively, and N is the total number

• br Experimental section br Results br Discussion

  2020-07-01

  

  Experimental section Results Discussion In our previous work (Rashidi et al., 2018) we isolated a novel glucarpidase whose raised Rofecoxib did not cross-react with the one in clinical use. In principle, therefore, it would be possible to delay the production of antibodies in a patient by

• Following Duncan as a ritualized site Tyne Cot provides

  2020-07-01

  

  Following Duncan (1995), as a ritualized site Tyne Cot provides an opportunity for individual tourists to conduct their own acts of remembrance (Edensor, 2000, Iles, 2006). The analysis has also shown that individual acts of writing particular words and phrases in the visitor books are socially shar

• br Method Detailed study protocol

  2020-07-01

  

  Method Detailed study protocol was reported previously. The ULTIMATE- HFrEF trial was approved by the Institutional Review Board of our hospital, and the study drug, udenafil, was approved as Investigational New Drug for treatment in patients with chronic HFrEF by Ministry of Food and Drug Safety

• The use of recombinant ER and ER binding

  2020-07-01

  

  The use of recombinant ERα and ERβ binding assays offers a relatively inexpensive, rapid technique for screening compounds for potential direct acetylcholine chloride receptor modulatory activity and understanding the mechanisms of existing herbal medicines. For background on the protein production

• br Expression and Tissue Functions of DDRs The DDRs

  2020-07-01

  

  Expression and Tissue Functions of DDRs The DDRs are widely expressed in different tissues, both during development and in adult organisms. DDR1 mRNA is found in many tissues in mice and humans, with high levels in brain, lung, kidney, spleen, and placenta (Di Marco et al., 1993, Johnson et al.,

• br STAR Methods br Microenvironmental niches

  2020-07-01

  

  STAR★Methods Microenvironmental niches for naïve and activated B cells Secondary lymphoid organs, such as the spleen and lymph nodes, are structurally and functionally compartmentalized to provide a set of microenvironmental niches that support the survival of resting B cells, as well as the a

• The DNA damage response DDR is a cellular mechanism

  2020-07-01

  

  The DNA damage response (DDR) is a cellular mechanism that protects against DNA damage induced by endogenous and exogenous factors, it includes changes in cellular processes such as BMS 753 receptor regulation, DNA damage repair, apoptosis and chromatin remodeling. In recent years, the DDR has been

• The biological significance of DNA ligases is attributed

  2020-07-01

  

  The biological significance of DNA ligases is attributed to their function in DNA replication, recombination and/or DNA repair [1], [2]. In vertebrates, three different DNA ligases I, III and IV are recognized. DNA ligase I is essential for the Okazaki fragments’ ligation during lagging-strand DNA s

• In neurodegenerative disorders neurons are excited

  2020-07-01

  

  In neurodegenerative disorders neurons are excited by enormous ionic flow which induces mitochondrial dysfunction and apoptosis. Glutamate as the main excitatory neurotransmitter, is released excessively in these diseases. Glutamate acts through N-methyl-d-aspartate (NMDA) receptor and α-amino-3-hyd

15853 records 801/1057 page Previous Next First page 上5页 801802803804805 下5页 Last page