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Cy3-UTP as a Molecular Probe for Intracellular RNA Traffi...
2025-09-23
Explore how Cy3-UTP, a photostable fluorescent RNA labeling reagent, enables advanced investigation of intracellular RNA trafficking and RNA-protein interactions in the context of nanoparticle delivery and endosomal dynamics. This article provides scientific insights and practical guidance for leveraging Cy3-UTP in RNA biology research.
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RSL3 and Ferroptosis: Deciphering Iron-Dependent Cell Dea...
2025-09-22
Explore how RSL3, a potent glutathione peroxidase 4 inhibitor, serves as a precise tool for dissecting ferroptosis signaling pathways, modulating oxidative stress, and advancing cancer research through ROS-mediated non-apoptotic cell death mechanisms.
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DMH1: Advancing Precision Control of BMP Signaling in Org...
2025-09-19
Explore how DMH1, a selective BMP type I receptor inhibitor, enables precise mo
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TNF-alpha Recombinant Murine Protein in Apoptotic Signali...
2025-09-18
Explore the applications of TNF-alpha recombinant murine protein in dissecting apoptotic signaling pathways, including its relevance to mitochondrial-mediated cell death and recent mechanistic insights. This article details technical specifications and research uses of recombinant TNF-alpha expressed in E. coli for advanced inflammation and cancer studies.
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Blocking the action of CREB
2025-03-03
Blocking the action of CREB with the C646 inhibitor together with increasing Akt activation with the SC79 agonist is particularly interesting as it significantly reduced wound closure time from 7 days (which is required for complete closure of control hTECs exposed to DMSO) to only 4 days (when hTEC
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Given the profound expression of HT A and HT
2025-03-03
Given the profound ep4 receptor of 5-HT1A and 5-HT2A in the hippocampal CA1 region, and their potential to complex with mGluRs, the objective of this study was to examine if sleep deprivation alters the expression of 5-HT1A and 5-HT2A receptors and determine whether potential changes are reversible
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Although ASD is considered one of the
2025-03-03
Although ASD is considered one of the most heritable neurodevelopmental disorders (El-Fishawy & State, 2010; Geschwind, 2011) and majority of the research on ASD has focused on the genetics of the disorders (Autism Genome Project, C, 2007; Buxbaum & Hof, 2011), single causative gene anomalies accoun
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Molecular docking simulations were carried out for ligands i
2025-03-03
Molecular docking simulations were carried out for ligands – in the ACE crystal structure (1O86) and DPP4 crystal structure (2G5P). Comparison of the binding mode of – () with enalaprilat (a) in ACE shows that the phenethyl group (–, enalaprilat) occupies the S1 pocket and the adjacent carboxylic li
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Our previous work fails to
2025-03-03
Our previous work fails to show any maternal effect with blockade of 5-HT2A receptor, as acute and repeated treatment of MDL100907 does not alter maternal behavior at the behaviorally active doses (Chen et al., 2014). In the present study, MDL100907 pretreatment attenuated the maternal disruptive ef
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NLX a k a F
2025-03-03
NLX-112 (a.k.a. F13640 or befiradol), exhibits nanomolar affinity at 5-HT1A receptors, and, in Bioorthogonal amino acid to the 5-HT1A receptor agonists listed above, it presents exceptional selectivity and high efficacy at these receptors (Colpaert et al., 2002, Newman-Tancredi et al., 2017). Addit
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GABAB receptor is associated with
2025-03-01
GABAB receptor is associated with CU CPT 4a and behavioral diseases, including epilepsy, spasticity, anxiety and neuropathic pain (Bettler et al., 2004, Bowery et al., 2002, Froestl, 2010). Baclofen, a clinical drug and selective GABAB receptor agonist, is used to treat muscle spasticity in patients
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Therefore the rational design of target compounds is based
2025-03-01
Therefore, the rational design of target compounds is based on the hybrid of attractive phenotypic bis-indole (5, Fig. 1) and sulfonamide moieties, in which the indole core might anticipate in hydrophobic interaction, and the functionality of sulfonamide group may involve in H-bonding with the site
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The R pycnus arginase was identical
2025-03-01
The R. pycnus arginase was 65% identical to the published B. caldovelox arginase sequence (AAB06939). Furthermore, the R. pycnus arginase gene was 62%, 45%, 36% and 22% identical to the published arginase sequences from Bacillus thuringiensis (AJI37018), Thermus thermophiles (WP_038039155), Human ar
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Formation of SAHFs in human cells is
2025-03-01
Formation of SAHFs in human WEHI-539 hydrochloride is a dynamic and multifaceted process that is largely dependent on the p16/pRB ras-induced senescence pathway [108]. Many details remain to be elucidated but formation appears to be driven by a complex of histone chaperones (HIRA and ASF1a), a pRB/
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Thiazole heterocycles constitute an interesting
2025-03-01
Thiazole heterocycles constitute an interesting class of molecules, which exhibit a broad spectrum of biological activity, including antifungal properties [[16], [17], [18], [19]]. Encouraged by our previous study that describes the activity of hydrazine-thiazole derivatives against C. gattii and C.